Alendroninezuur Ranbaxy may be available in the countries listed below.
Alendronic Acid sodium trihydrate (a derivative of Alendronic Acid) is reported as an ingredient of Alendroninezuur Ranbaxy in the following countries:
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Reasec may be available in the countries listed below.
Atropine sulfate (a derivative of Atropine) is reported as an ingredient of Reasec in the following countries:
Diphenhydramine hydrochloride (a derivative of Diphenhydramine) is reported as an ingredient of Reasec in the following countries:
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Enalaprilmaleat Alternova may be available in the countries listed below.
Enalapril maleate (a derivative of Enalapril) is reported as an ingredient of Enalaprilmaleat Alternova in the following countries:
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Ranfen may be available in the countries listed below.
Ibuprofen is reported as an ingredient of Ranfen in the following countries:
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Lorazepam is reported as an ingredient of PMS-Lorazepam in the following countries:
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Fumafer may be available in the countries listed below.
Ferrous Fumarate is reported as an ingredient of Fumafer in the following countries:
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Cefotaxime is reported as an ingredient of Cefotaxime Teva in the following countries:
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Prothin may be available in the countries listed below.
Amfepramone is reported as an ingredient of Prothin in the following countries:
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Anginine may be available in the countries listed below.
Nitroglycerin is reported as an ingredient of Anginine in the following countries:
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Meprox may be available in the countries listed below.
Omeprazole is reported as an ingredient of Meprox in the following countries:
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Fenofibrate is reported as an ingredient of Fénofibrate Ranbaxy in the following countries:
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Broncomax may be available in the countries listed below.
Bromhexine is reported as an ingredient of Broncomax in the following countries:
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Minigeste may be available in the countries listed below.
Ethinylestradiol is reported as an ingredient of Minigeste in the following countries:
Gestodene is reported as an ingredient of Minigeste in the following countries:
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Fluocinolone Acetonide (BANM, DCIT, JAN, USAN) is known as Fluocinolone in the US.
Neomycin sulfate (a derivative of Neomycin) is reported as an ingredient of Fluocinolone Acetonide in the following countries:
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Glossary
| BANM | British Approved Name (Modified) |
| DCIT | Denominazione Comune Italiana |
| JAN | Japanese Accepted Name |
| USAN | United States Adopted Name |
Metoprololtartrat Hexal may be available in the countries listed below.
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Impugan may be available in the countries listed below.
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Urografin® 150
Urografin®150 for infusion
Urografin® 370
Urografin 150: 1ml contains 40mg sodium amidotrizoate (sodium diatrizoate) and 260mg meglumine amidotrizoate (meglumine diatrizoate).
Urografin 370: 1ml contains 100mg sodium amidotrizoate (sodium diatrizoate) and 660mg meglumine amidotrizoate (meglumine diatrizoate).
Aqueous solution for injection
X-ray contrast medium for the delineation of the vascular and renal systems.
1. Adults only
The table below shows the medium/media the licence holder suggests for each investigation. These media may be used at the discretion of the radiologist for other established permutations of medium and examination which, for the sake of simplicity, have been omitted from the table.
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a If patients with cardiac insufficiency are given 100ml or more, an injection time of at least 20 - 30 minutes is recommended.
b100ml bottles are available for coronary arteriography.
(Other indications include: high dose urography, pelvic venography, venacavography, arthrography, selective visceral angiography, limb venography, jugular venography, vesiculography, sialography, sinusography, amniography,lymphangiography, intramuscular urography,operative cholangiography, percutaneous cholangiography, fistulography, oesophageal and anal atresia).
Urografin media are not suitable for myelography
2. Children and neonates
Intravenous urography: The fact that urograms of infants and young children generally show a lower contrast density than those of adults is explained by the physiologically less effective function of the immature nephron. Relatively high doses of media are therefore indicated. (See table below).
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Drip-infusion urography: Dosage of Urografin 150 should not exceed 4ml/kg body weight.
Angiocardiography: In neonates up to 5kg body weight, 8ml Urografin 370. Infants over 5kg body weight, 1ml/kg body weight up to 25ml per injection.
Right and left heart catheterisation: 1-1.2ml/kg body weight of Urografin 370, with a maximum of 15ml per injection for the right heart and 25ml per injection for the left heart.
Pulmonary angiography: 0.5-0.6ml/kg body weight up to 8ml Urografin 370 per injection.
• General Information
The patient should be recumbent during the administration of Urografin and kept under close observation for at least 30 minutes (See special warnings and special precautions for use).
Experience shows that contrast medium is tolerated better if it is warmed to body temperature.
Proven or suspected hypersensitivity to iodine-containing contrast media, uncontrolled thyrotoxicosis and decompensated cardiac insufficiency.
Hysterosalpingography must not be carried out during pregnancy or in patients with acute inflammatory conditions in the pelvic cavity.
For patients with severe impairment of hepatic or renal function, cerebral arteriosclerosis, epileptic conditions, diabetes mellitus requiring drug treatment and/or associated with diabetic complications, pulmonary emphysema, poor general health, latent hyperthyroidism, multiple myeloma or benign nodular goitre the need for examination with X-ray contrast media merits careful consideration.
This also applies to patients with a history of allergy, atopy, bronchial asthma, endogenous eczema, cardiac or circulatory insufficiency or a previous adverse reaction with any contrast medium since experience shows that they may be at higher risk from developing anaphylaxis or cardiovascular collapse. Consideration should be given to the use of low osmolar radiocontrast media in such patients.
The patient should be recumbent during the administration of Urografin. Thereafter, the patient must be kept under close observation for at least 30 minutes, since about 90% of all severe incidents occur within that time. If the administration does not take place on the X-ray table, any patient with a labile circulation should be brought to the X-ray machine sitting or lying down.
Particular caution should be exercised in allergic persons who have previously tolerated an injectable iodine-containing contrast medium without any complication because they may have become sensitized to these substances in the meantime.
As with any contrast medium, the possibility of hypersensitivity must always be considered. If marked side-effects or suspected allergic reactions occur during injection and do not disappear, or even get worse, when the injection is briefly interrupted, it is probable that the patient is hypersensitive and the investigation must be abandoned. Even relatively minor symptoms such as itching of the skin, sneezing, violent yawns, tickling in the throat, hoarseness or attacks of coughing may be early signs of a severe reaction and, therefore, merit careful attention.
Ionic iodinated contrast media inhibit blood coagulation in vitro more than non-ionic contrast media. Nevertheless medical personnel performing vascular catheterisation procedures should pay meticulous attention to the angiographic technique and catheter flushing so as to minimise the risk of procedure-related thrombosis and embolisation.
In patients with multiple myeloma, diabetes mellitus requiring drug treatment, polyuria, oliguria or gout, and in infants, young children and marasmic patients the fluid supply should not be restricted. Existing disturbances of the balance of water and electrolytes must be corrected before the administration of a hypertonic contrast-medium solution.
Premedication with an alpha-blocker is recommended in patients with phaeochromocytoma, because of the risk of hypertensive crisis.
If iodine isotopes are to be administered for the diagnosis of thyroid disease, it should be borne in mind that after the administration of iodinated contrast media which are excreted via the kidneys, the capacity of the thyroid tissue to take up iodine will be reduced for 2 weeks, and sometimes up to 6 weeks.
Experience shows that pronounced states of excitement, anxiety and pain can be the cause of side effects or intensify contrast medium-related reactions. They can be counteracted by calm management of the patient and the use of suitable drugs.
Diabetic nephropathy may predispose to renal impairment following intravascular administration of contrast media. This may precipitate lactic acidosis in patients who are taking biguanides. As a precaution biguanides should be stopped 48 hours prior to the examination and reinstated only after adequate renal function has been regained.
Hypersensitivity reactions can be aggravated in patients on beta-blockers.
The prevalence of delayed reactions (e. g. fever, rash, flu-like symptoms, joint pain and pruritus) to contrast media is higher in patients who have received interleukin.
X-ray examinations should if possible be avoided during pregnancy. It has not yet been proved beyond question that Urografin may be used without hesitation in pregnant patients. Therefore, an examination with a contrast medium during pregnancy should be carried out only if considered absolutely necessary by the physician.
Renally eliminated contrast media such as Urografin enter the breast milk in only very small amounts.
Limited data suggest that the risk to the suckling infant of administering salts of diatrizoic acid to its mother is low.
Delayed reactions following intravascular administration of iodinated contrast media are rare. Nevertheless, driving or operating machinery is not advisable for the first 24 hours.
Mild subjective symptoms, such as a feeling of heat and nausea, occur very seldom and disappear rapidly when the injection is slowed down or briefly interrupted.
Transient pain may occur, in particular during the examination of peripheral vascular regions.
Other symptoms which may occur are:
Chills, fever, sweating, headache, dizziness, blanching, weakness, gagging and a feeling of suffocation, gasping, a rise or fall of blood pressure, itching, urticaria, other kinds of skin eruption, oedema, cramp, tremor, sneezing and lacrimation. These reactions, which can occur irrespective of the amount administered and the mode of administration, may be the first signs of incipient shock. Administration of the contrast medium must be discontinued immediately and - if necessary - specific therapy instituted intravenously. It is therefore advisable to use a flexible indwelling cannula for intravenous contrast medium administration.
Very rarely, severe or even life-threatening side-effects such as severe hypotension and collapse, circulatory failure, ventricular fibrillation, cardiac arrest, pulmonary oedema, anaphylactic shock or other allergic manifestations, convulsions, or other cerebral symptoms may occur. In some cases these have proved fatal.
To permit immediate countermeasures to be taken in emergencies, appropriate drugs, an endotracheal tube and a ventilator should be ready to hand.
Experience shows that hypersensitivity reactions occur more frequently in patients with an allergic disposition.
Paravascular administration of the contrast medium rarely leads to severe tissue reactions.
Delayed reactions can occasionally occur.
Neurological complications such as coma, temporary states of confusion and somnolence, transient paresis, disturbed vision or facial muscle paresis and epileptic fits may occur after cerebral angiography and other procedures in which the contrast medium reaches the brain with the arterial blood. In very rare cases the induction of fits has been observed after intravenous administration of Urografin in epileptics and patients with focal brain damage. However, a causal relationship seems to be questionable.
Temporary renal failure may occur in rare cases.
Acute symptoms of poisoning are unlikely with intravascular administration. On inadvertent overdosage or in greatly impaired renal function, the contrast medium may be removed by dialysis, and the balance of water and electrolytes should be corrected. Acute toxicity studies do not suggest a risk of acute intoxication.
Urografin does not exert a pharmacological effect. It is an iodine - containing contrast medium, iodine being radio-opaque.
Absorption of amidotrizoic acid, the radiopaque component of Urografin, following oral administration is virtually nil. Plasma protein binding following intravenous injection amounts to less than 10%.
At diagnostic doses, amidotrizoic acid undergoes glomerular filtration.
Approximately 15% of the dose is eliminated in chemically unchanged form with the urine within 30 minutes after the injection, and more than 50% within 3 hours; no metabolites could be demonstrated.
In impaired renal function amidotrizoate can also be eliminated extrarenally via the liver, although at a distinctly reduced rate. Renal contrast media can easily be removed from the body by extracorporeal haemodialysis.
It is very quickly distributed in the extracelluar space following intravascular administration, but is not able to overcome an intact blood-brain barrier and is transmitted in only minimal amounts into breast milk.
There are no pre-clinical safety data which could be of relevance to the prescriber and which are not already included in other relevant sections of the SPC.
water for injection, sodium calcium edetate.
Some radiologists give an antihistamine or a corticoid prophylactically to patients with a history of allergy. However, because of the possibility of precipitation, X-ray contrast media and prophylactic agents must not be administered mixed together.
5 years
Protect from light and X-rays
Urografin 150: Packs of 10 x 10ml and 10 x 20ml glass ampoules.
Urografin 150 for infusion: Packs of 1 x 250ml and 1 x 500ml infusion bottles.
Urografin 370: Packs of 10 x 50 ml and 1 x 100 ml glass bottles.
The contrast medium solution should not be drawn into the syringe until immediately before the examination.
The infusion bottle should not be attached to the infusion set until immediately before the examination.
Ampoules or bottles containing contrast medium solutions are not intended for the withdrawal of multiple doses. The rubber stopper should never be pierced more than once.
Contrast medium not used in one examination session must be discarded.
Bayer plc
Bayer House
Strawberry Hill
Newbury
Berkshire RG14 1JA
United Kingdom
Trading as Bayer plc, Bayer Schering Pharma
Urografin 150 | 00010/0569 |
Urografin 150 for infusion | 00010/0568 |
Urografin 370 | 00010/0570 |
Urografin 150 | 01 May 2008 |
Urografin 150 for infusion | 01 May 2008 |
Urografin 370 | 01 May 2008 |
01 May 2008
POM
Losartan Mylan may be available in the countries listed below.
Losartan potassium salt (a derivative of Losartan) is reported as an ingredient of Losartan Mylan in the following countries:
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Laxocodyl may be available in the countries listed below.
Bisacodyl is reported as an ingredient of Laxocodyl in the following countries:
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Trazodona HCl MK may be available in the countries listed below.
Trazodone hydrochloride (a derivative of Trazodone) is reported as an ingredient of Trazodona HCl MK in the following countries:
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In some countries, this medicine may only be approved for veterinary use.
Rec.INN
0000548-62-9
C25-H30-Cl-N3
407
Disinfectant
Antiinfective
Dermatological agent: Topical antiseptic
Antifungal agent
Anthelmintic
N-[4-[Bis[4-(dimethylamino)phenyl]methylene]cyclohexa-2,5-dienylidene]-N-methylmethanaminium chloride (hexamethyl-p-rosanilinium chloride) (BP, Ph. Eur.)
[4-[Bis[p-(dimethyl-amino)phenyl]methylene]-2,5-cyclohexadien-1-ylidene]-dimethylammonium chloride (USAN)
Benzenemethanol, 4-(dimethylamino)-α,α-bis[4-(dimethylamino)phenyl]-, hydrochloride
Methanaminium, N-[4-[bis[4-(dimethylamino)phenyl]-methylene]-2,5-cyclohexadien-1-ylidene]-N-methyl-, chloride (USAN)
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Glossary
| BAN | British Approved Name |
| DCF | Dénomination Commune Française |
| IS | Inofficial Synonym |
| JAN | Japanese Accepted Name |
| OS | Official Synonym |
| PH | Pharmacopoeia Name |
| Rec.INN | Recommended International Nonproprietary Name (World Health Organization) |
| USAN | United States Adopted Name |
In some countries, this medicine may only be approved for veterinary use.
In the US, Penicillin VK (penicillin systemic) is a member of the drug class natural penicillins and is used to treat Actinomycosis, Anthrax, Anthrax Prophylaxis, Aspiration Pneumonia, Bacterial Infection, Clostridial Infection, Congenital Syphilis, Cutaneous Bacillus anthracis, Deep Neck Infection, Diphtheria, Endocarditis, Fusospirochetosis - Trench Mouth, Joint Infection, Leptospirosis, Lyme Disease - Arthritis, Lyme Disease - Carditis, Lyme Disease - Erythema Chronicum Migrans, Lyme Disease - Neurologic, Meningitis, Meningitis - Meningococcal, Meningitis - Pneumococcal, Neurosyphilis, Otitis Media, Pneumonia, Prevention of Perinatal Group B Streptococcal Disease, Rat-bite Fever, Rheumatic Fever Prophylaxis, Skin Infection, Strep Throat, Syphilis - Early, Syphilis - Latent, Tertiary Syphilis, Tonsillitis/Pharyngitis and Upper Respiratory Tract Infection.
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Phenoxymethylpenicillin potassium (a derivative of Phenoxymethylpenicillin) is reported as an ingredient of Penicillin VK in the following countries:
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Norethisterone 17ß-acetate (a derivative of Norethisterone) is reported as an ingredient of Estradiol and Norethidrone Acetate in the following countries:
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Eklips may be available in the countries listed below.
Losartan potassium salt (a derivative of Losartan) is reported as an ingredient of Eklips in the following countries:
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Kelvin may be available in the countries listed below.
Paracetamol is reported as an ingredient of Kelvin in the following countries:
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Embramine teoclate (a derivative of Embramine) is reported as an ingredient of Medrin in the following countries:
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In the US, Isocaine (mepivacaine systemic) is a member of the drug class local injectable anesthetics and is used to treat Local Anesthesia.
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FolliPlan may be available in the countries listed below.
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Altrenogest is reported as an ingredient of FolliPlan in the following countries:
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Cefuroxime axetil (a derivative of Cefuroxime) is reported as an ingredient of Cefuroxim Teva in the following countries:
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In the US, Limbitrol (amitriptyline/chlordiazepoxide systemic) is a member of the drug class psychotherapeutic combinations and is used to treat Anxiety and Depression.
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Ethinylestradiol is reported as an ingredient of Gestodiol in the following countries:
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Magnesium Hydrogen Aspartate dihydrate (a derivative of Magnesium Hydrogen Aspartate) is reported as an ingredient of Basti-Mag in the following countries:
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| BANM | British Approved Name (Modified) |
| USAN | United States Adopted Name |
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| DCIT | Denominazione Comune Italiana |
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Aldesleukin is reported as an ingredient of Proleukin in the following countries:
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| SPC | Summary of Product Characteristics (UK) |
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In the US, Modicon (ethinyl estradiol/norethindrone systemic) is a member of the following drug classes: contraceptives, sex hormone combinations and is used to treat Abnormal Uterine Bleeding, Acne, Birth Control, Endometriosis, Gonadotropin Inhibition, Menstrual Disorders, Polycystic Ovary Syndrome, Postmenopausal Symptoms and Prevention of Osteoporosis.
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| USAN | United States Adopted Name |
Meramyl may be available in the countries listed below.
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Phénothrine (DCF) is also known as Phenothrin (Rec.INN)
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| DCF | Dénomination Commune Française |
| Rec.INN | Recommended International Nonproprietary Name (World Health Organization) |
Lennon-Warfarin may be available in the countries listed below.
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Melatonin is reported as an ingredient of Amalar in the following countries:
International Drug Name Search
Chlorprothixen Leciva may be available in the countries listed below.
Chlorprothixene hydrochloride (a derivative of Chlorprothixene) is reported as an ingredient of Chlorprothixen Leciva in the following countries:
International Drug Name Search
Bronco Medical may be available in the countries listed below.
Dextromethorphan hydrobromide (a derivative of Dextromethorphan) is reported as an ingredient of Bronco Medical in the following countries:
Sulfogaiacol is reported as an ingredient of Bronco Medical in the following countries:
International Drug Name Search
Primperan may be available in the countries listed below.
Metoclopramide is reported as an ingredient of Primperan in the following countries:
Metoclopramide hydrochloride (a derivative of Metoclopramide) is reported as an ingredient of Primperan in the following countries:
International Drug Name Search
Cergem may be available in the countries listed below.
Gemeprost is reported as an ingredient of Cergem in the following countries:
International Drug Name Search
Adco-Nevirapine may be available in the countries listed below.
Nevirapine is reported as an ingredient of Adco-Nevirapine in the following countries:
International Drug Name Search
Prémélange Z27 may be available in the countries listed below.
In some countries, this medicine may only be approved for veterinary use.
Oxytetracycline is reported as an ingredient of Prémélange Z27 in the following countries:
Sulfadimidine is reported as an ingredient of Prémélange Z27 in the following countries:
International Drug Name Search
Motidine may be available in the countries listed below.
Famotidine is reported as an ingredient of Motidine in the following countries:
International Drug Name Search
Xipen may be available in the countries listed below.
Pentoxifylline is reported as an ingredient of Xipen in the following countries:
International Drug Name Search
Tranquinal may be available in the countries listed below.
Alprazolam is reported as an ingredient of Tranquinal in the following countries:
International Drug Name Search
Ferotym may be available in the countries listed below.
Sodium Ferrous Citrate is reported as an ingredient of Ferotym in the following countries:
International Drug Name Search
Isotroin may be available in the countries listed below.
Isotretinoin is reported as an ingredient of Isotroin in the following countries:
International Drug Name Search
Benzylpénicilline procaïne may be available in the countries listed below.
Benzylpénicilline procaïne (DCF) is also known as Benzylpenicillin (Rec.INN)
International Drug Name Search
Glossary
| DCF | Dénomination Commune Française |
| Rec.INN | Recommended International Nonproprietary Name (World Health Organization) |
